Kaposi's sarcoma: aetiopathogenesis, histology and clinical features
Identifieur interne : 009104 ( Main/Exploration ); précédent : 009103; suivant : 009105Kaposi's sarcoma: aetiopathogenesis, histology and clinical features
Auteurs : Fm Buonaguro ; Ml Tornesello ; L. Buonaguro ; Ra Satriano [Italie] ; E. Ruocco [Italie] ; G. Castello [Italie] ; V. Ruocco [Italie]Source :
- Journal of the European Academy of Dermatology and Venereology [ 0926-9959 ] ; 2003-03.
Abstract
Kaposi's sarcoma (KS) represents today one of the most common skin cancers in transplanted Mediterranean subjects and, since the epidemic of human immunodeficiency virus/acquired immune deficiency syndrome, in young unmarried single men. The disease has been associated with the recent identified human herpesvirus (HHV)‐8 or KS herpesvirus and its incidence in the general population shows a north to south gradient that parallels the HHV‐8 increasing prevalence from Nordic countries to sub‐Saharan regions. The identification of the aetiopathogenetic mechanisms (viral agents and immunodeficiency) involved in the pathogenesis of KS, are relevant for identifying susceptible subjects (HHV‐8 seropositive subjects), monitoring the immune levels in iatrogenic immune suppressed patients, and developing new therapeutic approaches based on antiviral and immune modulators.
Url:
DOI: 10.1046/j.1468-3083.2003.00670.x
Affiliations:
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The disease has been associated with the recent identified human herpesvirus (HHV)‐8 or KS herpesvirus and its incidence in the general population shows a north to south gradient that parallels the HHV‐8 increasing prevalence from Nordic countries to sub‐Saharan regions. The identification of the aetiopathogenetic mechanisms (viral agents and immunodeficiency) involved in the pathogenesis of KS, are relevant for identifying susceptible subjects (HHV‐8 seropositive subjects), monitoring the immune levels in iatrogenic immune suppressed patients, and developing new therapeutic approaches based on antiviral and immune modulators.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Buonaguro, Fm" sort="Buonaguro, Fm" uniqKey="Buonaguro F" first="Fm" last="Buonaguro">Fm Buonaguro</name><name sortKey="Buonaguro, L" sort="Buonaguro, L" uniqKey="Buonaguro L" first="L" last="Buonaguro">L. 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